RE: Kidney Xplant w new skin cancer: Best IS recipe 6 hours ago

I too am not aware of nicotinamide use for SCC . Systemic retinoids, particularly oral acitretin has been used for SCC prevention, but has adverse ...

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RE: Kidney Xplant w new skin cancer: Best IS recipe 7 hours ago

As far as I know, nicotinamide is not effective in prevention or therapy of squamous cell sjim cancer developing in an immunosuppressed transplant ...

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RE: C3G- What's Next 8 hours ago

Many thanks. The "real life" experiences with a novel are very valuable to the practicing physician, who often is lacking in reference points due t...

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RE: C3G- What's Next 8 hours ago

So, we have 8 patients in Pegcetacoplan and 1 on Iptacopan for C3G and IC- MPGN. While they all qualified for expensive treatments from their insu...

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RE: C3G- What's Next 9 hours ago

I do not recall that we got the full biopsy report. The question is always what trigger or drive the disease. Did the patient have genetic testi...

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RE: Use Of Ace Inhibitor/Arab For A Single Kidney 10 hours ago

You are so welcome Dr Safdar To add a great article from KI about management of patients with acquired single kidney. -----------------------...

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RE: Use Of Ace Inhibitor/Arab For A Single Kidney 10 hours ago

Dr Aledan thanks very helpful Thanks for the reference --------------------------------- Shahzad Safdar MD Mt. Auburn Nephrology, Inc. Cincinn...

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RE: True hyponatremia and normal osmolality 12 hours ago

I hate to enter into the fray and prolong this thread but I thought I would put in my two cents just to unify the comments of Drs. Asplin, Uribarri...

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RE: Use Of Ace Inhibitor/Arab For A Single Kidney 14 hours ago

There is no strong evidence or guideline recommendation for prescribing ACE inhibitors (ACEi) or angiotensin receptor blockers (ARBs) solely to pre...

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Use Of Ace Inhibitor/Arab For A Single Kidney 16 hours ago

Question for the panel. Have a patient donated kidney to his mother. Blood pressure 120/80. No Albuminuria or proteinuria. Does he need to be on Ac...

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RE: Transplant Question 17 hours ago

Could you send a picture of the virtual cross match please ------------------------------ Daniel Guevara-Pineda MD West Hartford CT ------------...

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RE: Kidney Xplant w new skin cancer: Best IS recipe 17 hours ago

While BCC is more common than SCC in the general population, reverse applies in the transplant population. Azathioprine is associated with increase...

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RE: Kidney Xplant w new skin cancer: Best IS recipe 20 hours ago

Because the SCC associated with MMF in kidney transplant recipients are usually of a non-agressive histological type, I would favor a modest reduct...

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RE: Kidney Xplant w new skin cancer: Best IS recipe 21 hours ago

Appreciate Dr Venkat comments and sharing the thread from 2017 which reviewd this topic. Turns out my patient has squamous cell skin cancer not B...

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RE: IV iron chelators 22 hours ago

I am honored by your invitation and look forward to the opportunity to participate in this interesting discussion. In the early eighties, when I w...

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RE: membranous nephropathy and multiple myeloma 1 day ago

Thanks for the notions. I also thought that Daratumumab would be appropriate, and I will suggest it again to our hematologists. IgG subclass sta...

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RE: Transplant Question 1 day ago

HLA-B locus homozygosity means that the donor inherited the same HLA-B antigen from both parents. In other words, donor's HLA-B locus paternal and ...

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RE: Transplant Question 1 day ago

Thanks prof glassock Why is it b mm not 2 if homyzogous ? --------------------------------- Muhammad Soobadar MBChB UK -----------------------...

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RE: True hyponatremia and normal osmolality 1 day ago

:(…not at ASN…yes, Sosm = total body osm/TBW so (I guess) if there was a gain of particles (made in RBCs), it would increase Sosm…but there’s also ...

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RE: Transplant Question 1 day ago

The 112 designation refers to the # of mismatched antogen at the HLA-A , HLA -B and HLA-DR/DQ loci respectively- so one antigen was mismatched at t...

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RE: Transplant Question 1 day ago

The meeting concluded that to go on kidney sharing scheme for couple of run and accept 221 mismatch rather than 2DR mismatch Young age and would ...

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RE: treatment 1 day ago

forgot to attach, how could that happen? :) ------------------------------ Roger Rodby MD, FASN Professor of Medicine Rush Uni...

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RE: treatment 1 day ago

For what it is worth, While I know that Prot/Cr ratios are not that reliable in AKI, A level of 12 g/g NS "Nephrotic syndrome" suggests a podocytop...

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2025 Fellows-In-Training Bowl Starts Tomorrow Live in Houston! 1 day ago

The 2025 ASN FIT Bowl Games will kick off at 10:30 am CST tomorrow, November 6, 2025. The games will be held in the ASN Futures Theater in the Geor...

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RE: membranous nephropathy and multiple myeloma 1 day ago

Was IgG subclass staining of the kidney biopsy ever undertaken (as suggested previously) ------------------------------ Richard Glassock MD, FAS...

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RE: Transplant Question 1 day ago

Sorry- i cannot interpret these reports except that the XM is negative and the ABO is compatible. The donor is Homozygous at the HLA-B locus, ...

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RE: Transplant Question 1 day ago

Hi Prof Glassock i have attached files would be grateful for an explanation ------------------------------ Muhammad Soobadar MBChB UK --...

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RE: treatment 1 day ago

With this degree of proteinurua (as estimated by UPCR on a "spot urine " ) it is unlikely that the decline in kidney function is due to TIN only. H...

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RE: Transplant Question 1 day ago

What do you mean by "HLA mismatch 112". Please clarify you question by giving a full description of HLA typing in the Donor and Recipient. ------...

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RE: membranous nephropathy and multiple myeloma 1 day ago

This seems to be high risk Smildering MM or overt MM (considering the severe anemia ) of an IgA -IgG L biclonal type. The pathology findings are of...

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Transplant Question 1 day ago

Dear colleagues , Silly question HLA mismatch 112 • Donor is homozygous at HLA-B, there is no matching at this locus What does it mean ?

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RE: membranous nephropathy and multiple myeloma 1 day ago

Free light chains ratio was normal since the diagnosis of membranous nephropathy and MM, and declined to 0.24 on the first time on 16/10/25 when IG...

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RE: membranous nephropathy and multiple myeloma 1 day ago

Dr. Glassock what would be the reasons to treat? My understanding is that this patients, according to IMMWG criteria, has smoldering - and not act...

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RE: membranous nephropathy and multiple myeloma 1 day ago

Thanks for all your comments. The proteinuria is mainly albuminuria. BJ was negative. In immunofluoroscence of the kidney biosy a granular stai...

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RE: treatment 2 days ago

One thing, I started steroid treatment empirically as you said. ------------------------------ Yuki Teragawa Futabanosato Prefectural Hospital Hi...

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RE: treatment 2 days ago

Urine test shows red blood cells, and UPCR is 12 g/gCr. I didn't check UACR. The blood test shows slight C4 elevation. Finally, I stopped the medic...

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RE: membranous nephropathy and multiple myeloma 2 days ago

Like Dr. Rodby- i am confused. Did the MN aldo show Lambda LC monotypism? Was Pronase digestion pursued? It seems that you have plenty of reasons t...

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RE: membranous nephropathy and multiple myeloma 2 days ago

CD20/CD19 cell counts after initial myeloma treatment and currently? In view of reaction to rituximab-biosimilar, should obintuzumab be consider...

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RE: Kidney Xplant w new skin cancer: Best IS recipe 2 days ago

Any proteinuria (may contraindicate use of mTOR-Is)? What is the dermatologist's assessment of the BCC: has it been completely excised/how aggressi...

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RE: Cautious tale : IVIG and Sglt2i 2 days ago

In our institution we stopped using the sucrose-containing IVIG preparation Sandoglobulin because it contained sucrose as the stabilizer and may ca...

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RE: C3G- What's Next 2 days ago

Not sure I understood " indirect" acting monoclonal disease . Did u mean monoclonal antibody activating the complement system ? Thank u ---------...

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RE: C3G- What's Next 2 days ago

I have no idea what to do next. I would predict that the disease will relapse if you stop the Pegcetacoplan. Are you sure that an indirect acting m...

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RE: Cautious tale : IVIG and Sglt2i 2 days ago

To my knowledge, sucrose (a disaccharide) is neither metabolized nor reabsorbed by the proximal tubule. It behaves very much like mannitol as a non...

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C3G- What's Next 2 days ago

Hello ... We have now reached the 9 month anniversary of the use of Pegcetacoplan in a patient with IC-MPGN and around 40% IFTA. The patient was 5...

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Kidney Xplant w new skin cancer: Best IS recipe 2 days ago

Need help sorting out best recipe for IS in the folllowing 70 y/o DDTx premptive ( nevere on dialysis) 9/2024 PRA 27%, KDPI 82% esrd d/t HTN never ...

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RE: Cautious tale : IVIG and Sglt2i 2 days ago

Dr Argyropolous was a sucrose containing or sucrose- free IVIg preparation used in this case? thanks ------------------------------ Emilio Vent...

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RE: possible SLE/CTD to biopsy or not. 2 days ago

Hi prof rodby ( they say old is gold )! Till new post I thought evidence was for scc and mtor And reduction of is with monitoring of dsa/ dna may...

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RE: possible SLE/CTD to biopsy or not. 2 days ago

you should repost this as a NEW post. thanks ------------------------------ Roger Rodby MD, FASN Professor of Medicine Rush University Nephrol...

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RE: possible SLE/CTD to biopsy or not. 2 days ago

Need help sorting out best recipe for IS in the folllowing 70 y/o DDTx premptive ( nevere on dialysis) 9/2024 PRA 27%, KDPI 82% esrd d/t HTN never ...

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RE: Cautious tale : IVIG and Sglt2i 2 days ago

I'm buying it "hook line and sinker", such i good story I dont care if it is wrong. Few things give me more joy (in medicine) than thinking outs...

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